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KMID : 0377619970620020165
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Korean Jungang Medical Journal
1997 Volume.62 No. 2 p.165 ~ p.172
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Effect of Vitamin E Administration on Mitogenic Responses and Interleukin-2 Production in Mice
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Abstract
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The present study was undertaken to investigate the of effects of vitamin E administration on the mitogenic responses of murine splenocytes, to PHA, Con A or PWM and on the interleukin-2(IL-2) production of the splenocytes, employing the proliferation bioassay using IL-2 dependent CTLL-2 cells. Mice were given daily 300 mg of vitamin E for 10 days or given daily 100 mg for 30 days by esophageal intubation(0.1 ml). Vehicle control mice were 0.1 ml of corn oil by esophageal intubation for 10 days or 30 days and untreated mice were employed as nor oral control. The daily administration of 300 mg of vitamin E for 10 days did not cause any change in the mitogenic responses to PHA, Con A or PWM of the splenocytes. However, daily administration of 100 mg of vitamin E for 30 days significantly enhanced the mitogenic responses as compared with control mice. Interestingly, the daily administration of 100 mg of vitamin for 30 days enhanced the capability of IL-2 production of murine splenocytes. Taken together, the present data strongly suggested that the daily administration of vitamin(100 mg) for 30 days may enhance significantly both mitogen-mediated T and B lymphocyte proliferation by spleen cells and the IL-2 production of spleen cells in mice, and these studies also suggested that vitamin E is a potent immunomodulator.
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KEYWORD
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